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The AmoyDx® OncoPro Liquid NGS Panel is a next-generation sequencing (NGS)-based assay designed for the qualitative detection of single nucleotide variants (SNVs), insertions and deletions (InDels), gene fusions, and copy number variations (CNVs) across 152 target genes, as well as for determining tumor microsatellite instability (MSI) status. The panel detects these genetic alterations using circulating cell-free DNA (cfDNA) extracted from plasma, derived from anticoagulated peripheral whole blood samples.

Mutations( Hover over each mutational type to highlight genes covered )

All
CNV
FUSIONS
SNV/INDELS
ABRAXAS1

ABRAXAS1

SNV/INDELS
AKT1

AKT1

SNV/INDELS
AKT2

AKT2

SNV/INDELS
AKT3

AKT3

SNV/INDELS
ALK

ALK

FUSIONS
SNV/INDELS
APC

APC

SNV/INDELS
AR

AR

FUSIONS
SNV/INDELS
ARAF

ARAF

SNV/INDELS
ARID1A

ARID1A

SNV/INDELS
ATM

ATM

SNV/INDELS
ATR

ATR

SNV/INDELS
AURKA

AURKA

SNV/INDELS
B2M

B2M

SNV/INDELS
BAP1

BAP1

SNV/INDELS
BARD1

BARD1

SNV/INDELS
BCL2L11

BCL2L11

SNV/INDELS
BRAF

BRAF

FUSIONS
SNV/INDELS
BRCA1

BRCA1

CNV
SNV/INDELS
BRCA2

BRCA2

CNV
SNV/INDELS
BRIP1

BRIP1

SNV/INDELS
CCND1

CCND1

SNV/INDELS
CCND2

CCND2

SNV/INDELS
CCNE1

CCNE1

SNV/INDELS
CD274

CD274

SNV/INDELS
CDH1

CDH1

SNV/INDELS
CDK12

CDK12

SNV/INDELS
CDK4

CDK4

SNV/INDELS
CDK6

CDK6

SNV/INDELS
CDKN2A

CDKN2A

SNV/INDELS
CDKN2B

CDKN2B

SNV/INDELS
CHEK1

CHEK1

SNV/INDELS
CHEK2

CHEK2

SNV/INDELS
CTNNB1

CTNNB1

SNV/INDELS
CYP2D6

CYP2D6

SNV/INDELS
DDR2

DDR2

SNV/INDELS
DPYD

DPYD

SNV/INDELS
EGFR

EGFR

FUSIONS
SNV/INDELS
EPCAM

EPCAM

SNV/INDELS
ERBB2

ERBB2

CNV
FUSIONS
SNV/INDELS
ERBB3

ERBB3

SNV/INDELS
ERBB4

ERBB4

FUSIONS
SNV/INDELS
ERCC1

ERCC1

SNV/INDELS
ERCC2

ERCC2

SNV/INDELS
ERCC3

ERCC3

SNV/INDELS
ERCC4

ERCC4

SNV/INDELS
ESR1

ESR1

FUSIONS
SNV/INDELS
EZH2

EZH2

SNV/INDELS
FANCA

FANCA

SNV/INDELS
FANCD2

FANCD2

SNV/INDELS
FANCL

FANCL

SNV/INDELS
FANCM

FANCM

SNV/INDELS
FBXW7

FBXW7

SNV/INDELS
FGF19

FGF19

SNV/INDELS
FGF3

FGF3

SNV/INDELS
FGFR1

FGFR1

FUSIONS
SNV/INDELS
FGFR2

FGFR2

FUSIONS
SNV/INDELS
FGFR3

FGFR3

FUSIONS
SNV/INDELS
FGFR4

FGFR4

FUSIONS
SNV/INDELS
FH

FH

SNV/INDELS
GATA3

GATA3

SNV/INDELS
GEN1

GEN1

SNV/INDELS
GNA11

GNA11

SNV/INDELS
GNAQ

GNAQ

SNV/INDELS
GNAS

GNAS

SNV/INDELS
HDAC2

HDAC2

SNV/INDELS
HNF1A

HNF1A

SNV/INDELS
HRAS

HRAS

SNV/INDELS
IDH1

IDH1

SNV/INDELS
IDH2

IDH2

SNV/INDELS
JAK1

JAK1

SNV/INDELS
JAK2

JAK2

SNV/INDELS
JAK3

JAK3

SNV/INDELS
KDR

KDR

SNV/INDELS
KEAP1

KEAP1

SNV/INDELS
KIT

KIT

FUSIONS
SNV/INDELS
KRAS

KRAS

SNV/INDELS
MAP2K1

MAP2K1

SNV/INDELS
MAP2K2

MAP2K2

SNV/INDELS
MAP2K4

MAP2K4

SNV/INDELS
MAPK1

MAPK1

SNV/INDELS
MAPK3

MAPK3

SNV/INDELS
MDM2

MDM2

SNV/INDELS
MDM4

MDM4

SNV/INDELS
MET

MET

CNV
FUSIONS
SNV/INDELS
MLH1

MLH1

SNV/INDELS
MPL

MPL

SNV/INDELS
MRE11

MRE11

SNV/INDELS
MSH2

MSH2

SNV/INDELS
MSH6

MSH6

SNV/INDELS
MTAP

MTAP

SNV/INDELS
MTOR

MTOR

SNV/INDELS
MUTYH

MUTYH

SNV/INDELS
MYC

MYC

SNV/INDELS
MYCN

MYCN

SNV/INDELS
NBN

NBN

SNV/INDELS
NF1

NF1

SNV/INDELS
NF2

NF2

SNV/INDELS
NFE2L2

NFE2L2

SNV/INDELS
NOTCH1

NOTCH1

SNV/INDELS
NPM1

NPM1

SNV/INDELS
NRAS

NRAS

SNV/INDELS
NRG1

NRG1

FUSIONS
SNV/INDELS
NTRK1

NTRK1

FUSIONS
SNV/INDELS
NTRK2

NTRK2

FUSIONS
SNV/INDELS
NTRK3

NTRK3

FUSIONS
SNV/INDELS
PALB2

PALB2

SNV/INDELS
PDCD1

PDCD1

SNV/INDELS
PDGFRA

PDGFRA

FUSIONS
SNV/INDELS
PIK3CA

PIK3CA

CNV
SNV/INDELS
PIK3CB

PIK3CB

SNV/INDELS
PIK3R1

PIK3R1

SNV/INDELS
PMS2

PMS2

SNV/INDELS
POLD1

POLD1

SNV/INDELS
POLE

POLE

SNV/INDELS
PPARG

PPARG

SNV/INDELS
PTCH1

PTCH1

SNV/INDELS
PTEN

PTEN

CNV
SNV/INDELS
PTPN11

PTPN11

SNV/INDELS
RAD50

RAD50

SNV/INDELS
RAD51

RAD51

SNV/INDELS
RAD51B

RAD51B

SNV/INDELS
RAD51C

RAD51C

SNV/INDELS
RAD51D

RAD51D

SNV/INDELS
RAD52

RAD52

SNV/INDELS
RAD54L

RAD54L

SNV/INDELS
RAF1

RAF1

FUSIONS
SNV/INDELS
RASA1

RASA1

SNV/INDELS
RB1

RB1

SNV/INDELS
RET

RET

FUSIONS
SNV/INDELS
RHEB

RHEB

SNV/INDELS
RHOA

RHOA

SNV/INDELS
RICTOR

RICTOR

SNV/INDELS
RIT1

RIT1

SNV/INDELS
RNF43

RNF43

SNV/INDELS
ROS1

ROS1

FUSIONS
SNV/INDELS
SETD2

SETD2

SNV/INDELS
SF3B1

SF3B1

SNV/INDELS
SLX4

SLX4

SNV/INDELS
SMAD4

SMAD4

SNV/INDELS
SMARCA4

SMARCA4

SNV/INDELS
SMO

SMO

SNV/INDELS
STK11

STK11

SNV/INDELS
TERT

TERT

FUSIONS
SNV/INDELS
TMPRSS2

TMPRSS2

FUSIONS
SNV/INDELS
TP53

TP53

SNV/INDELS
TSC1

TSC1

SNV/INDELS
TSC2

TSC2

SNV/INDELS
TSHR

TSHR

SNV/INDELS
UGT1A1

UGT1A1

SNV/INDELS
VHL

VHL

SNV/INDELS
XRCC1

XRCC1

SNV/INDELS
XRCC2

XRCC2

SNV/INDELS

Specifications

Sample Type
Plasma ctDNA
Tests/kit
24 reactions/kit
Target Regions
152 genes plus MSI
Instrument
Illumina NextSeq 500/550/550Dx (RUO), NovaSeq 6000

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