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The AmoyDx® Myeloid Blood Cancer Panel employs next-generation sequencing (NGS) technology to qualitatively detect and identify single nucleotide variants (SNVs), insertions and deletions (InDels), and gene fusions within 55 genes associated with myeloid leukemia. This assay utilizes DNA and RNA extracted from bone marrow aspirate specimens obtained from patients diagnosed with acute myeloid leukemia or chronic myeloid leukemia.
 

 

Single Assay Solution for Detecting Variants Associated with Acute Myeloid Leukemia (AML) and Chronic Myeloid Leukemia (CML) Using Both DNA & RNA


Mutations( Hover over each mutational type to highlight genes covered )

All
FUSIONS
SNV/INDELS
ABL1

ABL1

FUSIONS
SNV/INDELS
ASXL1

ASXL1

SNV/INDELS
BCOR

BCOR

SNV/INDELS
BRAF

BRAF

SNV/INDELS
CALR

CALR

SNV/INDELS
CBFB

CBFB

FUSIONS
SNV/INDELS
CBL

CBL

SNV/INDELS
CEBPA

CEBPA

SNV/INDELS
CREBBP

CREBBP

FUSIONS
SNV/INDELS
CSF3R

CSF3R

SNV/INDELS
CTCF

CTCF

SNV/INDELS
DIS3

DIS3

SNV/INDELS
DNMT3A

DNMT3A

SNV/INDELS
ETV6

ETV6

FUSIONS
SNV/INDELS
EZH2

EZH2

SNV/INDELS
FBXW7

FBXW7

SNV/INDELS
FLT3

FLT3

SNV/INDELS
GATA1

GATA1

SNV/INDELS
GATA2

GATA2

SNV/INDELS
IDH1

IDH1

SNV/INDELS
IDH2

IDH2

SNV/INDELS
IKZF1

IKZF1

SNV/INDELS
JAK2

JAK2

FUSIONS
SNV/INDELS
JAK3

JAK3

SNV/INDELS
KIT

KIT

SNV/INDELS
KMT2A

KMT2A

FUSIONS
SNV/INDELS
KRAS

KRAS

SNV/INDELS
MAX

MAX

SNV/INDELS
MPL

MPL

SNV/INDELS
MYC

MYC

SNV/INDELS
MYD88

MYD88

SNV/INDELS
MLLT10

MLLT10

FUSIONS
NF1

NF1

SNV/INDELS
NPM1

NPM1

FUSIONS
SNV/INDELS
NRAS

NRAS

SNV/INDELS
NUP98

NUP98

FUSIONS
SNV/INDELS
NUP214

NUP214

FUSIONS
PDGFRA

PDGFRA

FUSIONS
SNV/INDELS
PHF6

PHF6

SNV/INDELS
PTPN11

PTPN11

SNV/INDELS
RB1

RB1

SNV/INDELS
RIT1

RIT1

SNV/INDELS
RUNX1

RUNX1

FUSIONS
SNV/INDELS
RARA

RARA

FUSIONS
SETBP1

SETBP1

SNV/INDELS
SF3B1

SF3B1

SNV/INDELS
SRSF2

SRSF2

SNV/INDELS
STAG2

STAG2

SNV/INDELS
STIL

STIL

FUSIONS
TET2

TET2

SNV/INDELS
TP53

TP53

SNV/INDELS
TCF3

TCF3

FUSIONS
U2AF1

U2AF1

SNV/INDELS
WT1

WT1

SNV/INDELS
ZRSR2

ZRSR2

SNV/INDELS

Specifications

Sample type
Bone Marrow
Alterations detected
SNV、Indel、Fusion
Sequencer
NovaSeq 6000, NextSeq 500/550, MiSeq, MiSeqDx
TAT from sample to report
3 days

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