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The AmoyDx® HANDLE HRR NGS Panel facilitates the detection of somatic and germline variants across 27 genes within the Homologous Recombination Repair (HRR) pathway, along with 5 tumor driver genes.





 

Mutations( Hover over each mutational type to highlight genes covered )

All
LR
SNV/INDELS
BRCA1

BRCA1

LR
SNV/INDELS
BRCA2

BRCA2

LR
SNV/INDELS
AR

AR

SNV/INDELS
ATM

ATM

SNV/INDELS
ATR

ATR

SNV/INDELS
BARD1

BARD1

SNV/INDELS
BRIP1

BRIP1

SNV/INDELS
CDH1

CDH1

SNV/INDELS
CDK12

CDK12

SNV/INDELS
CHEK1

CHEK1

SNV/INDELS
CHEK2

CHEK2

SNV/INDELS
ESR1

ESR1

SNV/INDELS
FANCA

FANCA

SNV/INDELS
FANCL

FANCL

SNV/INDELS
HDAC2

HDAC2

SNV/INDELS
HOXB13

HOXB13

SNV/INDELS
MRE11

MRE11

SNV/INDELS
NBN

NBN

SNV/INDELS
PALB2

PALB2

SNV/INDELS
PPP2R2A

PPP2R2A

SNV/INDELS
PTEN

PTEN

SNV/INDELS
RAD51B

RAD51B

SNV/INDELS
RAD51C

RAD51C

SNV/INDELS
RAD51D

RAD51D

SNV/INDELS
RAD54L

RAD54L

SNV/INDELS
STK11

STK11

SNV/INDELS
TP53

TP53

SNV/INDELS
BRAF

BRAF

SNV/INDELS
ERBB2

ERBB2

SNV/INDELS
KRAS

KRAS

SNV/INDELS
NRAS

NRAS

SNV/INDELS
PIK3CA

PIK3CA

SNV/INDELS

Secure data analysis and interpretation

Secure data analysis and interpretation

Detection of SNV, InDel and germline LR for BRCA1/BRCA2

Detection of SNV, InDel and germline LR for BRCA1/BRCA2

Fast turnaround time and cost-effective

Fast turnaround time and cost-effective

Streamlined one-tube workflow

Streamlined one-tube workflow

Specifications

Target regions
27 HRR genes: All coding regions, exon-intron boundaries of AR, ATM, ATR, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CDK12, CHEK1, CHEK2, ESR1, FANCA, FANCL, HDAC2, HOXB13, MRE11, NBN, PALB2, PPP2R2A, PTEN, RAD51B, RAD51C, RAD51D, RAD54L, STK11 and TP53.
5 driver genes (BRAF, ERBB2, KRAS, NRAS, PIK3CA): hotspot regions
Alterations detected
SNV, Indel (somatic/germline), LR (germline for BRCA1/2)
Sample type
Fresh-frozen/FFPE tissue, whole blood
DNA input
Optimal 100ng (FFPE/fresh tissue ≥30ng, whole blood ≥20ng)
Data output per Sample
0.35 Gb for germline variants, 0.7 Gb for somatic variants
Sequencing type
PE150
Sequencer
Illumina iSeq 100, MiniSeq, MiSeq, NextSeq 500, NovaSeq 6000
TAT for library preparation
5 hours (hands-on time < 1 hour )
TAT from sample to report
3 days

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