AmoyDx ® HANDLE Hereditary Cancer NGS Panel
NGS
Inquiry
The AmoyDx ® HANDLE Hereditary Cancer NGS Panel is designed for the qualitative detection of single nucleotide variants (SNVs) and insertions and deletions (InDels) of 150 cancer susceptibility genes and large rearrangement (LR) deletions of 8 genes (BRCA1, BRCA2, MLH1, MSH6, PMS2, EPCAM, and VHL) using DNA extracted from peripheral whole blood specimens.
Comprehensive Hereditary Cancer Testing in One Integrated Workflow
Comprehensive Gene Coverage
• 150 cancer predisposition genes analyzed
• Detection of SNVs/InDels across all genes + CNVs in 8 key genes
Broad Scope of Utility
• Identifies all major hereditary cancer syndromes, including: Hereditary Breast and Ovarian Cancer, Lynch Syndrome,
Li-Fraumeni Syndrome, PTEN Hamartoma Tumor, Syndrome (PHTS), and other high-risk genetic disorders
• One test evaluates hereditary risks for pan-cancer types
Automated Reporting with Actionable Insights
Automated Reports delivering actionable insights for tailored surveillance and prevention
• Hereditary cancer syndrome linked to each result
• Cancer types with elevated risk
• Curated interpretation of key variants
Fast and Streamlined Workflow
• Proprietary HANDLE technology with one-tube workflow
• <1 hour hands-on time, <5 hours total library preparation
Addressing Key Gaps in Hereditary Cancer Research
The AmoyDx® HANDLE Hereditary Cancer Panel overcomes the limits of broad or narrow testing approaches:
Mutations( Hover over each mutational type to highlight genes covered )
All
ABRAXAS1
ABRAXAS1
SNV/INDELS
AIP
AIP
SNV/INDELS
ALK
ALK
SNV/INDELS
APC
APC
SNV/INDELS
ASXL1
ASXL1
SNV/INDELS
ATM
ATM
SNV/INDELS
ATR
ATR
SNV/INDELS
ATRIP
ATRIP
SNV/INDELS
AXIN2
AXIN2
SNV/INDELS
BAP1
BAP1
SNV/INDELS
BARD1
BARD1
SNV/INDELS
BLM
BLM
SNV/INDELS
BMPR1A
BMPR1A
SNV/INDELS
BRAF
BRAF
SNV/INDELS
BRCA1
BRCA1
LR
SNV/INDELS
BRCA2
BRCA2
LR
SNV/INDELS
BRIP1
BRIP1
SNV/INDELS
BUB1
BUB1
SNV/INDELS
BUB3
BUB3
SNV/INDELS
CDC73
CDC73
SNV/INDELS
CDH1
CDH1
SNV/INDELS
CDK12
CDK12
SNV/INDELS
CDK4
CDK4
SNV/INDELS
CDKN1B
CDKN1B
SNV/INDELS
CDKN1C
CDKN1C
SNV/INDELS
CDKN2A
CDKN2A
SNV/INDELS
CFTR
CFTR
SNV/INDELS
CHEK1
CHEK1
SNV/INDELS
CHEK2
CHEK2
SNV/INDELS
CTNNA1
CTNNA1
SNV/INDELS
DDB2
DDB2
SNV/INDELS
DDX41
DDX41
SNV/INDELS
DICER1
DICER1
SNV/INDELS
DIS3L2
DIS3L2
SNV/INDELS
DLST
DLST
SNV/INDELS
EGFR
EGFR
SNV/INDELS
ELAC2
ELAC2
SNV/INDELS
EPCAM
EPCAM
LR
SNV/INDELS
ERCC1
ERCC1
SNV/INDELS
ERCC2
ERCC2
SNV/INDELS
ERCC3
ERCC3
SNV/INDELS
ERCC4
ERCC4
SNV/INDELS
ERCC5
ERCC5
SNV/INDELS
EXT1
EXT1
SNV/INDELS
EXT2
EXT2
SNV/INDELS
FAN1
FAN1
SNV/INDELS
FANCA
FANCA
SNV/INDELS
FANCB
FANCB
SNV/INDELS
FANCC
FANCC
SNV/INDELS
FANCD2
FANCD2
SNV/INDELS
FANCE
FANCE
SNV/INDELS
FANCF
FANCF
SNV/INDELS
FANCG
FANCG
SNV/INDELS
FANCI
FANCI
SNV/INDELS
FANCL
FANCL
SNV/INDELS
FANCM
FANCM
SNV/INDELS
FH
FH
SNV/INDELS
FLCN
FLCN
SNV/INDELS
FOXE1
FOXE1
SNV/INDELS
GALNT12
GALNT12
SNV/INDELS
GEN1
GEN1
SNV/INDELS
GNAS
GNAS
SNV/INDELS
GPR101
GPR101
SNV/INDELS
GREM1
GREM1
SNV/INDELS
HDAC2
HDAC2
SNV/INDELS
HNF1A
HNF1A
SNV/INDELS
HNF1B
HNF1B
SNV/INDELS
HOXB13
HOXB13
SNV/INDELS
HRAS
HRAS
SNV/INDELS
KIT
KIT
SNV/INDELS
LRP6
LRP6
SNV/INDELS
MAD2L2
MAD2L2
SNV/INDELS
MAX
MAX
SNV/INDELS
MBD4
MBD4
SNV/INDELS
MC1R
MC1R
SNV/INDELS
MEN1
MEN1
SNV/INDELS
MET
MET
SNV/INDELS
MITF
MITF
SNV/INDELS
MLH1
MLH1
LR
SNV/INDELS
MLH3
MLH3
SNV/INDELS
MRE11
MRE11
SNV/INDELS
MSH2
MSH2
LR
SNV/INDELS
MSH3
MSH3
SNV/INDELS
MSH6
MSH6
LR
SNV/INDELS
MUTYH
MUTYH
SNV/INDELS
NBN
NBN
SNV/INDELS
NF1
NF1
SNV/INDELS
NF2
NF2
SNV/INDELS
NTHL1
NTHL1
SNV/INDELS
NTRK1
NTRK1
SNV/INDELS
PALB2
PALB2
SNV/INDELS
PALLD
PALLD
SNV/INDELS
PDGFRA
PDGFRA
SNV/INDELS
PMS2
PMS2
LR
SNV/INDELS
POLD1
POLD1
SNV/INDELS
POLE
POLE
SNV/INDELS
POLE2
POLE2
SNV/INDELS
POLH
POLH
SNV/INDELS
POT1
POT1
SNV/INDELS
PPP2R2A
PPP2R2A
SNV/INDELS
PRKAR1A
PRKAR1A
SNV/INDELS
PRSS1
PRSS1
SNV/INDELS
PTCH1
PTCH1
SNV/INDELS
PTEN
PTEN
SNV/INDELS
RAD50
RAD50
SNV/INDELS
RAD51
RAD51
SNV/INDELS
RAD51B
RAD51B
SNV/INDELS
RAD51C
RAD51C
SNV/INDELS
RAD51D
RAD51D
SNV/INDELS
RAD54L
RAD54L
SNV/INDELS
RB1
RB1
SNV/INDELS
RBBP8
RBBP8
SNV/INDELS
RECQL
RECQL
SNV/INDELS
RECQL4
RECQL4
SNV/INDELS
REST
REST
SNV/INDELS
RET
RET
SNV/INDELS
RHBDF2
RHBDF2
SNV/INDELS
RNASEL
RNASEL
SNV/INDELS
RNF43
RNF43
SNV/INDELS
RPS20
RPS20
SNV/INDELS
SDHA
SDHA
SNV/INDELS
SDHAF2
SDHAF2
SNV/INDELS
SDHB
SDHB
SNV/INDELS
SDHC
SDHC
SNV/INDELS
SDHD
SDHD
SNV/INDELS
SLC25A11
SLC25A11
SNV/INDELS
SLX4
SLX4
SNV/INDELS
SMAD4
SMAD4
SNV/INDELS
SMARCA2
SMARCA2
SNV/INDELS
SMARCA4
SMARCA4
SNV/INDELS
SMARCB1
SMARCB1
SNV/INDELS
SPINK1
SPINK1
SNV/INDELS
STK11
STK11
SNV/INDELS
SUFU
SUFU
SNV/INDELS
TERT
TERT
SNV/INDELS
TGFBR2
TGFBR2
SNV/INDELS
TMEM127
TMEM127
SNV/INDELS
TP53
TP53
SNV/INDELS
TRIM37
TRIM37
SNV/INDELS
TRIP13
TRIP13
SNV/INDELS
TSC1
TSC1
SNV/INDELS
TSC2
TSC2
SNV/INDELS
UBE2T
UBE2T
SNV/INDELS
VHL
VHL
LR
SNV/INDELS
WRN
WRN
SNV/INDELS
WT1
WT1
SNV/INDELS
XPA
XPA
SNV/INDELS
XPC
XPC
SNV/INDELS
XRCC2
XRCC2
SNV/INDELS
XRCC3
XRCC3
SNV/INDELS
Specifications
Shelf-life
-25℃ to -15℃ for 12 months
Tests/kit
24
Instrument
NovaSeqv6000, NextSeq 500/550Dx, MiSeq / MiSeqDx
Inquiry