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Critical biomarkers guiding pan-cancer targeted therapy have emerged, emphasizing the importance of detecting multiple gene mutations in cancer patients for precise and effective treatment. The AmoyDx HANDLE Classic Panel encompasses 40 key solid tumor genes, enabling the detection of common mutations to support clinical therapeutic decisions with rapid turnaround time (TAT).

Mutations( Hover over each mutational type to highlight genes covered )

All
CNV
FUSIONS
SNP
SNV/INDELS
AKT1

AKT1

SNV/INDELS
ALK

ALK

FUSIONS
SNV/INDELS
BRAF

BRAF

SNV/INDELS
CTNNB1

CTNNB1

SNV/INDELS
DDR2

DDR2

SNV/INDELS
EGFR

EGFR

SNV/INDELS
ERBB2

ERBB2

CNV
SNV/INDELS
ESR1

ESR1

SNV/INDELS
FGFR1

FGFR1

FUSIONS
SNV/INDELS
FGFR2

FGFR2

FUSIONS
SNV/INDELS
FGFR3

FGFR3

FUSIONS
SNV/INDELS
FGFR4

FGFR4

SNV/INDELS
HRAS

HRAS

SNV/INDELS
IDH1

IDH1

SNV/INDELS
IDH2

IDH2

SNV/INDELS
KEAP1

KEAP1

SNV/INDELS
KIT

KIT

SNV/INDELS
KRAS

KRAS

SNV/INDELS
MAP2K1

MAP2K1

SNV/INDELS
MET

MET

CNV
FUSIONS
SNV/INDELS
NFE2L2

NFE2L2

SNV/INDELS
NRAS

NRAS

SNV/INDELS
NTRK1

NTRK1

FUSIONS
SNV/INDELS
NTRK2

NTRK2

FUSIONS
SNV/INDELS
NTRK3

NTRK3

FUSIONS
SNV/INDELS
PDGFRA

PDGFRA

SNV/INDELS
PIK3CA

PIK3CA

SNV/INDELS
POLE

POLE

SNV/INDELS
PTEN

PTEN

SNV/INDELS
RB1

RB1

SNV/INDELS
RET

RET

FUSIONS
SNV/INDELS
ROS1

ROS1

FUSIONS
SNV/INDELS
STK11

STK11

SNV/INDELS
TP53

TP53

SNV/INDELS
CDK4

CDK4

CNV
DPYD

DPYD

SNP
MYC

MYC

CNV
NKX2-1

NKX2-1

CNV
NRG1

NRG1

FUSIONS
UGT1A1

UGT1A1

SNP

Target 40 clinically actionable genes plus MSI

Target 40 clinically actionable genes plus MSI

Detection of SNV, Indel, fusion, CNV and MSI

Detection of SNV, Indel, fusion, CNV and MSI

Fast turnaround time within 3 days

Fast turnaround time within
3 days

Automatic and secure data analysis

Automatic and secure data analysis

Specifications

Sample type
FFPE
Alterations detected
SNV, InDel, Fusion, CNV, MSI
DNA input
minimum 50 ng DNA and 30 ng RNA

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