Comprehensive Genomic Profiling (CGP) assays are increasingly utilized in clinical practices, offering an efficient means of maximizing the utility of limited tissue biopsies by assessing multiple cancer-relevant biomarkers simultaneously. By covering actionable and emerging biomarkers, CGP assays hold promise in identifying diverse therapeutic pathways and innovative clinical trial options for cancer patients.
The “Most Comprehensive”
Genomic Profiling Assay
Gain actionable molecular insights
on 48 cancer types
The AmoyDx Master Panel facilitates the concurrent detection of both DNA and RNA biomarkers. On the DNA level, it encompasses 571 genes, encompassing biomarkers associated with approved targeted therapies, as well as those recommended by guidelines/consensus or under investigation in clinical trials. In addition to SNV/indel, fusion, and CNV analysis, the Master Panel also evaluates complex signatures such as HRD, MSI, and TMB. On the RNA level, it surveys over 2000 genes, detecting fusions and alternative splicing while analyzing levels of genes implicated in cancer pathways. Furthermore, it enables the assessment of select immunotherapy biomarkers like GEP and TME.
The “Most Comprehensive”
Genomic Profiling Assay
Gain actionable molecular insights
on 48 cancer types
The AmoyDx Master Panel facilitates the concurrent detection of both DNA and RNA biomarkers. On the DNA level, it encompasses 571 genes, encompassing biomarkers associated with approved targeted therapies, as well as those recommended by guidelines/consensus or under investigation in clinical trials. In addition to SNV/indel, fusion, and CNV analysis, the Master Panel also evaluates complex signatures such as HRD, MSI, and TMB. On the RNA level, it surveys over 2000 genes, detecting fusions and alternative splicing while analyzing levels of genes implicated in cancer pathways. Furthermore, it enables the assessment of select immunotherapy biomarkers like GEP and TME.
Mutations( Hover over each mutational type to highlight genes covered )
All
ABL1
ABL1
FUSIONS
SNV/INDELS
ABR
ABR
FUSIONS
ACADM
ACADM
FUSIONS
ADAMTS16
ADAMTS16
FUSIONS
AFAP1
AFAP1
FUSIONS
AFF3
AFF3
FUSIONS
AGAP3
AGAP3
FUSIONS
AGBL4
AGBL4
FUSIONS
AGGF1
AGGF1
FUSIONS
AGK
AGK
FUSIONS
AGTRAP
AGTRAP
FUSIONS
AHCYL1
AHCYL1
FUSIONS
AKAP13
AKAP13
FUSIONS
AKAP9
AKAP9
FUSIONS
ALAD
ALAD
FUSIONS
ALK
ALK
FUSIONS
SNV/INDELS
AMBRA1
AMBRA1
FUSIONS
AMOT
AMOT
FUSIONS
AMOTL2
AMOTL2
FUSIONS
ANO3
ANO3
FUSIONS
AP1M1
AP1M1
FUSIONS
AP3B1
AP3B1
FUSIONS
SNV/INDELS
APIP
APIP
FUSIONS
APOLD1
APOLD1
FUSIONS
AR
AR
FUSIONS
SNV/INDELS
ARHGEF2
ARHGEF2
FUSIONS
ARMC10
ARMC10
FUSIONS
ASPSCR1
ASPSCR1
FUSIONS
ATF7IP
ATF7IP
FUSIONS
ATG7
ATG7
FUSIONS
ATIC
ATIC
FUSIONS
ATP1B1
ATP1B1
FUSIONS
ATP6V1D
ATP6V1D
FUSIONS
BAG4
BAG4
FUSIONS
BAIAP2L1
BAIAP2L1
FUSIONS
BCAN
BCAN
FUSIONS
BCL2L11
BCL2L11
FUSIONS
SNV/INDELS
BCL2L14
BCL2L14
FUSIONS
BCR
BCR
FUSIONS
SNV/INDELS
BICC1
BICC1
FUSIONS
BRAF
BRAF
FUSIONS
SNV/INDELS
BTBD1
BTBD1
FUSIONS
BTF3L4
BTF3L4
FUSIONS
C8orf34
C8orf34
FUSIONS
SNP
CACNA2D1
CACNA2D1
FUSIONS
CAPZA2
CAPZA2
FUSIONS
CASP7
CASP7
FUSIONS
CAV1
CAV1
FUSIONS
CBR4
CBR4
FUSIONS
CBX5
CBX5
FUSIONS
CCAR2
CCAR2
FUSIONS
CCDC186
CCDC186
FUSIONS
CCDC6
CCDC6
FUSIONS
CCDC91
CCDC91
FUSIONS
CD74
CD74
FUSIONS
SNV/INDELS
CDC27
CDC27
FUSIONS
CDK12
CDK12
FUSIONS
HD
SNV/INDELS
CEP43
CEP43
FUSIONS
CEP72
CEP72
FUSIONS
CEP85L
CEP85L
FUSIONS
CEP89
CEP89
FUSIONS
CHTOP
CHTOP
FUSIONS
CIDEA
CIDEA
FUSIONS
CIT
CIT
FUSIONS
CLCN6
CLCN6
FUSIONS
CLDN18
CLDN18
FUSIONS
CLIP1
CLIP1
FUSIONS
CLTC
CLTC
FUSIONS
CNIH4
CNIH4
FUSIONS
CNTRL
CNTRL
FUSIONS
COL14A1
COL14A1
FUSIONS
COL16A1
COL16A1
FUSIONS
CREB5
CREB5
FUSIONS
CTNNA3
CTNNA3
FUSIONS
CTRC
CTRC
FUSIONS
CTTN
CTTN
FUSIONS
CUX1
CUX1
FUSIONS
CWH43
CWH43
FUSIONS
CYSTM1
CYSTM1
FUSIONS
DCTN1
DCTN1
FUSIONS
DDX21
DDX21
FUSIONS
DGCR2
DGCR2
FUSIONS
DHX15
DHX15
FUSIONS
DIAPH1
DIAPH1
FUSIONS
DUSP6
DUSP6
FUSIONS
DYNC1I2
DYNC1I2
FUSIONS
DZANK1
DZANK1
FUSIONS
EEF1G
EEF1G
FUSIONS
EGFR
EGFR
CNV
FUSIONS
SNP
SNV/INDELS
EIF1
EIF1
FUSIONS
EIF2AK3
EIF2AK3
FUSIONS
EIF3L
EIF3L
FUSIONS
EIF4A2
EIF4A2
FUSIONS
SNV/INDELS
ELAVL3
ELAVL3
FUSIONS
EML4
EML4
FUSIONS
EPS15
EPS15
FUSIONS
ERBB2
ERBB2
CNV
FUSIONS
SNV/INDELS
ERBB4
ERBB4
FUSIONS
SNV/INDELS
ERC1
ERC1
FUSIONS
ERG
ERG
FUSIONS
SNV/INDELS
ERLIN2
ERLIN2
FUSIONS
ERP44
ERP44
FUSIONS
ESR1
ESR1
FUSIONS
SNV/INDELS
ETV1
ETV1
FUSIONS
SNV/INDELS
ETV4
ETV4
FUSIONS
SNV/INDELS
ETV5
ETV5
FUSIONS
SNV/INDELS
ETV6
ETV6
FUSIONS
SNV/INDELS
EWSR1
EWSR1
FUSIONS
SNV/INDELS
EZR
EZR
FUSIONS
F11
F11
FUSIONS
F11R
F11R
FUSIONS
FAM114A2
FAM114A2
FUSIONS
FAM131B
FAM131B
FUSIONS
FBXO28
FBXO28
FUSIONS
FCHSD1
FCHSD1
FUSIONS
FGFR1
FGFR1
CNV
FUSIONS
SNV/INDELS
FGFR1OP2
FGFR1OP2
FUSIONS
FGFR2
FGFR2
CNV
FUSIONS
SNV/INDELS
FGFR3
FGFR3
CNV
FUSIONS
SNV/INDELS
FGFR4
FGFR4
FUSIONS
SNV/INDELS
FILIP1
FILIP1
FUSIONS
FIP1L1
FIP1L1
FUSIONS
FKBP15
FKBP15
FUSIONS
FLI1
FLI1
FUSIONS
FLT3
FLT3
FUSIONS
SNV/INDELS
FN1
FN1
FUSIONS
FOXO1
FOXO1
FUSIONS
SNV/INDELS
GAB2
GAB2
FUSIONS
GCGR
GCGR
FUSIONS
GHITM
GHITM
FUSIONS
GIT2
GIT2
FUSIONS
GKAP1
GKAP1
FUSIONS
GLOD4
GLOD4
FUSIONS
GOLGA5
GOLGA5
FUSIONS
GOPC
GOPC
FUSIONS
GRB10
GRB10
FUSIONS
GRIPAP1
GRIPAP1
FUSIONS
GTF2I
GTF2I
FUSIONS
GTF2IRD1
GTF2IRD1
FUSIONS
GYG1
GYG1
FUSIONS
HEY1
HEY1
FUSIONS
SNV/INDELS
HIP1
HIP1
FUSIONS
HLA-A
HLA-A
FUSIONS
SNV/INDELS
HNRNPA2B1
HNRNPA2B1
FUSIONS
HSF2BP
HSF2BP
FUSIONS
IKZF3
IKZF3
FUSIONS
INSL4
INSL4
FUSIONS
IRF2BP2
IRF2BP2
FUSIONS
JAK2
JAK2
FUSIONS
SNV/INDELS
JAKMIP1
JAKMIP1
FUSIONS
KCTD8
KCTD8
FUSIONS
KDM7A
KDM7A
FUSIONS
KIAA1217
KIAA1217
FUSIONS
KIAA1549
KIAA1549
FUSIONS
KIAA1598
KIAA1598
FUSIONS
KIF5B
KIF5B
FUSIONS
KIT
KIT
FUSIONS
SNV/INDELS
KLC1
KLC1
FUSIONS
KLHL7
KLHL7
FUSIONS
KLK2
KLK2
FUSIONS
LAMC1
LAMC1
FUSIONS
LIMA1
LIMA1
FUSIONS
LMNA
LMNA
FUSIONS
LOH12CR1
LOH12CR1
FUSIONS
LRRC71
LRRC71
FUSIONS
LSM12
LSM12
FUSIONS
LSM14A
LSM14A
FUSIONS
LUC7L2
LUC7L2
FUSIONS
LZTFL1
LZTFL1
FUSIONS
MAD1L1
MAD1L1
FUSIONS
MAGI3
MAGI3
FUSIONS
MEF2D
MEF2D
FUSIONS
MET
MET
CNV
FUSIONS
SNV/INDELS
MGEA5
MGEA5
FUSIONS
MKRN1
MKRN1
FUSIONS
MLLT10
MLLT10
FUSIONS
MORC3
MORC3
FUSIONS
MPRIP
MPRIP
FUSIONS
MSN
MSN
FUSIONS
MYB
MYB
FUSIONS
SNV/INDELS
MYH9
MYH9
FUSIONS
MYO18A
MYO18A
FUSIONS
MYO5A
MYO5A
FUSIONS
MYRIP
MYRIP
FUSIONS
MZT1
MZT1
FUSIONS
NAB2
NAB2
FUSIONS
SNV/INDELS
NACC2
NACC2
FUSIONS
NCOA2
NCOA2
FUSIONS
SNV/INDELS
NCOA4
NCOA4
FUSIONS
NFASC
NFASC
FUSIONS
NFIB
NFIB
FUSIONS
NOL4
NOL4
FUSIONS
NOS1AP
NOS1AP
FUSIONS
NOTCH2
NOTCH2
FUSIONS
SNV/INDELS
NPM1
NPM1
FUSIONS
SNV/INDELS
NR4A3
NR4A3
FUSIONS
SNV/INDELS
NRAP
NRAP
FUSIONS
NRBF2
NRBF2
FUSIONS
NRG1
NRG1
FUSIONS
NRG2
NRG2
FUSIONS
NRG3
NRG3
FUSIONS
NSD1
NSD1
FUSIONS
SNV/INDELS
NTRK1
NTRK1
FUSIONS
SNV/INDELS
NTRK2
NTRK2
FUSIONS
SNV/INDELS
NTRK3
NTRK3
CNV
FUSIONS
SNV/INDELS
NUB1
NUB1
FUSIONS
NUP214
NUP214
FUSIONS
OCIAD1
OCIAD1
FUSIONS
OFD1
OFD1
FUSIONS
OXR1
OXR1
FUSIONS
PAN3
PAN3
FUSIONS
PAPD7
PAPD7
FUSIONS
PAPSS1
PAPSS1
FUSIONS
PAWR
PAWR
FUSIONS
PAX8
PAX8
FUSIONS
SNV/INDELS
PCM1
PCM1
FUSIONS
PDE7A
PDE7A
FUSIONS
PDE9A
PDE9A
FUSIONS
PDGFB
PDGFB
FUSIONS
SNV/INDELS
PDGFRA
PDGFRA
CNV
FUSIONS
SNV/INDELS
PDGFRB
PDGFRB
FUSIONS
SNV/INDELS
PEAR1
PEAR1
FUSIONS
PGAP3
PGAP3
FUSIONS
PHC3
PHC3
FUSIONS
PHF12
PHF12
FUSIONS
PHLDB3
PHLDB3
FUSIONS
PLEKHG6
PLEKHG6
FUSIONS
PMEPA1
PMEPA1
FUSIONS
PML
PML
FUSIONS
POC1B
POC1B
FUSIONS
POF1B
POF1B
FUSIONS
PPARG
PPARG
FUSIONS
SNV/INDELS
PPFIBP1
PPFIBP1
FUSIONS
PPHLN1
PPHLN1
FUSIONS
PPL
PPL
FUSIONS
PPP1R1B
PPP1R1B
FUSIONS
PPP1R21
PPP1R21
FUSIONS
PPP4R3B
PPP4R3B
FUSIONS
PRDX1
PRDX1
FUSIONS
SNP
PRKAR1A
PRKAR1A
FUSIONS
SNV/INDELS
PRKAR2A
PRKAR2A
FUSIONS
PSMB3
PSMB3
FUSIONS
PSPH
PSPH
FUSIONS
PTGFRN
PTGFRN
FUSIONS
PWWP2A
PWWP2A
FUSIONS
QKI
QKI
FUSIONS
SNV/INDELS
RAB3IL1
RAB3IL1
FUSIONS
RABGAP1L
RABGAP1L
FUSIONS
RAD18
RAD18
FUSIONS
RAF1
RAF1
FUSIONS
SNV/INDELS
RANBP2
RANBP2
FUSIONS
SNV/INDELS
RARA
RARA
FUSIONS
SNV/INDELS
RBMS3
RBMS3
FUSIONS
RBPMS
RBPMS
FUSIONS
REG4
REG4
FUSIONS
RET
RET
CNV
FUSIONS
SNV/INDELS
RNF130
RNF130
FUSIONS
RNF213
RNF213
FUSIONS
ROCK1
ROCK1
FUSIONS
ROS1
ROS1
FUSIONS
SNV/INDELS
RPL3
RPL3
FUSIONS
RTN4RL1
RTN4RL1
FUSIONS
SARS
SARS
FUSIONS
SCP2
SCP2
FUSIONS
SCYL3
SCYL3
FUSIONS
SDC4
SDC4
FUSIONS
SEC22B
SEC22B
FUSIONS
SEC31A
SEC31A
FUSIONS
SEC61G
SEC61G
FUSIONS
SEPT10
SEPT10
FUSIONS
SEPT14
SEPT14
FUSIONS
SEPTIN3
SEPTIN3
FUSIONS
SHROOM3
SHROOM3
FUSIONS
SHTN1
SHTN1
FUSIONS
SIL1
SIL1
FUSIONS
SLC12A7
SLC12A7
FUSIONS
SLC34A2
SLC34A2
FUSIONS
SLC3A2
SLC3A2
FUSIONS
SLC43A2
SLC43A2
FUSIONS
SLMAP
SLMAP
FUSIONS
SMARCE1
SMARCE1
FUSIONS
SND1
SND1
FUSIONS
SORBS1
SORBS1
FUSIONS
SPAG17
SPAG17
FUSIONS
SPECC1L
SPECC1L
FUSIONS
SQSTM1
SQSTM1
FUSIONS
SS18
SS18
FUSIONS
SNV/INDELS
SSBP2
SSBP2
FUSIONS
SSX1
SSX1
FUSIONS
SSX2
SSX2
FUSIONS
ST7
ST7
FUSIONS
STARD3
STARD3
FUSIONS
STAT3
STAT3
FUSIONS
SNV/INDELS
STAT6
STAT6
FUSIONS
SNV/INDELS
STK26
STK26
FUSIONS
STMN2
STMN2
FUSIONS
STRN
STRN
FUSIONS
STRN3
STRN3
FUSIONS
TACC1
TACC1
FUSIONS
TACC2
TACC2
FUSIONS
TACC3
TACC3
FUSIONS
TANK
TANK
FUSIONS
TATDN1
TATDN1
FUSIONS
TAX1BP1
TAX1BP1
FUSIONS
TBC1D1
TBC1D1
FUSIONS
TBC1D2
TBC1D2
FUSIONS
TBL1XR1
TBL1XR1
FUSIONS
TEAD2
TEAD2
FUSIONS
TFE3
TFE3
FUSIONS
SNV/INDELS
TFG
TFG
FUSIONS
TLCD2
TLCD2
FUSIONS
TLE4
TLE4
FUSIONS
TLE5
TLE5
FUSIONS
TMEFF2
TMEFF2
FUSIONS
TMEM106B
TMEM106B
FUSIONS
TMEM165
TMEM165
FUSIONS
TMPRSS2
TMPRSS2
FUSIONS
SNV/INDELS
TP53
TP53
FUSIONS
HD
SNP
SNV/INDELS
TP73
TP73
FUSIONS
TPD52L1
TPD52L1
FUSIONS
TPM1
TPM1
FUSIONS
TPM3
TPM3
FUSIONS
TPM4
TPM4
FUSIONS
TPR
TPR
FUSIONS
TRAF1
TRAF1
FUSIONS
TRAF2
TRAF2
FUSIONS
TRAK1
TRAK1
FUSIONS
TRIM24
TRIM24
FUSIONS
TRIM27
TRIM27
FUSIONS
TRIM33
TRIM33
FUSIONS
TRIM63
TRIM63
FUSIONS
TXLNA
TXLNA
FUSIONS
USP10
USP10
FUSIONS
USP8
USP8
FUSIONS
UST
UST
FUSIONS
VCAN
VCAN
FUSIONS
VCL
VCL
FUSIONS
VIM
VIM
FUSIONS
VOPP1
VOPP1
FUSIONS
VSTM2A
VSTM2A
FUSIONS
WAC
WAC
FUSIONS
WDCP
WDCP
FUSIONS
WIPF2
WIPF2
FUSIONS
WNK2
WNK2
FUSIONS
XXYLT1
XXYLT1
FUSIONS
YWHAE
YWHAE
FUSIONS
SNV/INDELS
ZAN
ZAN
FUSIONS
ZC3HAV1
ZC3HAV1
FUSIONS
ZCCHC8
ZCCHC8
FUSIONS
ZMYM2
ZMYM2
FUSIONS
ZMYM4
ZMYM4
FUSIONS
ZNF34
ZNF34
FUSIONS
ZNF485
ZNF485
FUSIONS
ZNF703
ZNF703
FUSIONS
SNV/INDELS
ZSCAN30
ZSCAN30
FUSIONS
ABCB1
ABCB1
SNP
SNV/INDELS
ABL2
ABL2
SNV/INDELS
ABRAXAS1
ABRAXAS1
SNV/INDELS
ACVR1B
ACVR1B
SNV/INDELS
AGO1
AGO1
SNV/INDELS
AKT1
AKT1
SNV/INDELS
AKT2
AKT2
CNV
SNP
SNV/INDELS
AKT3
AKT3
CNV
SNV/INDELS
ALOX12B
ALOX12B
SNV/INDELS
AMER1
AMER1
SNV/INDELS
APC
APC
SNV/INDELS
APC2
APC2
SNV/INDELS
APEX1
APEX1
SNP
ARAF
ARAF
SNV/INDELS
ARFRP1
ARFRP1
SNV/INDELS
ARID1A
ARID1A
SNV/INDELS
ARID1B
ARID1B
SNV/INDELS
ARID2
ARID2
SNV/INDELS
ARID5B
ARID5B
SNV/INDELS
ASXL1
ASXL1
SNV/INDELS
ATM
ATM
HD
SNP
SNV/INDELS
ATR
ATR
SNV/INDELS
ATRX
ATRX
SNV/INDELS
AURKA
AURKA
CNV
SNP
SNV/INDELS
AURKB
AURKB
SNV/INDELS
AUTS2
AUTS2
SNP
AXIN1
AXIN1
SNV/INDELS
AXIN2
AXIN2
SNV/INDELS
AXL
AXL
SNV/INDELS
B2M
B2M
SNV/INDELS
BAP1
BAP1
SNV/INDELS
BARD1
BARD1
HD
SNV/INDELS
BCL2
BCL2
SNV/INDELS
BCL2L1
BCL2L1
SNV/INDELS
BCL2L2
BCL2L2
SNV/INDELS
BCL6
BCL6
SNV/INDELS
BCOR
BCOR
SNV/INDELS
BCORL1
BCORL1
SNV/INDELS
BIRC3
BIRC3
SNV/INDELS
BLK
BLK
SNV/INDELS
BLM
BLM
SNV/INDELS
BMP2
BMP2
SNP
BMP4
BMP4
SNP
BMPR1A
BMPR1A
SNV/INDELS
BRCA1
BRCA1
HD
SNV/INDELS
BRCA2
BRCA2
HD
SNV/INDELS
BRD3
BRD3
SNV/INDELS
BRD4
BRD4
SNV/INDELS
BRIP1
BRIP1
HD
SNV/INDELS
BTG1
BTG1
SNV/INDELS
BTK
BTK
SNV/INDELS
CALR
CALR
SNV/INDELS
CARD11
CARD11
SNV/INDELS
CASP8
CASP8
SNV/INDELS
CBFB
CBFB
SNV/INDELS
CBL
CBL
SNV/INDELS
CBLB
CBLB
SNP
CCN6
CCN6
SNV/INDELS
CCND1
CCND1
CNV
SNV/INDELS
CCND2
CCND2
SNV/INDELS
CCND3
CCND3
SNV/INDELS
CCNE1
CCNE1
SNV/INDELS
CD274
CD274
CNV
SNV/INDELS
CD34
CD34
SNV/INDELS
CD44
CD44
SNP
CD79A
CD79A
SNV/INDELS
CD79B
CD79B
SNV/INDELS
CD80
CD80
SNV/INDELS
CD86
CD86
SNV/INDELS
CDA
CDA
SNP
CDC73
CDC73
SNV/INDELS
CDH1
CDH1
HD
SNV/INDELS
CDK4
CDK4
CNV
SNV/INDELS
CDK6
CDK6
CNV
SNV/INDELS
CDK8
CDK8
SNV/INDELS
CDKN1A
CDKN1A
SNV/INDELS
CDKN1B
CDKN1B
SNV/INDELS
CDKN2A
CDKN2A
SNV/INDELS
CDKN2B
CDKN2B
SNV/INDELS
CDKN2C
CDKN2C
SNV/INDELS
CEBPA
CEBPA
SNV/INDELS
CHD2
CHD2
SNV/INDELS
CHD4
CHD4
SNV/INDELS
CHEK1
CHEK1
HD
SNV/INDELS
CHEK2
CHEK2
HD
SNV/INDELS
CIC
CIC
SNV/INDELS
CORO2A
CORO2A
SNP
CREBBP
CREBBP
SNV/INDELS
CRKL
CRKL
SNV/INDELS
CRLF2
CRLF2
SNV/INDELS
CSF1
CSF1
SNV/INDELS
CSF1R
CSF1R
SNV/INDELS
CSF3R
CSF3R
SNV/INDELS
CTCF
CTCF
SNV/INDELS
CTLA4
CTLA4
SNV/INDELS
CTNNA1
CTNNA1
SNV/INDELS
CTNNB1
CTNNB1
SNV/INDELS
CUL3
CUL3
SNV/INDELS
CXCL8
CXCL8
SNP
CYLD
CYLD
SNV/INDELS
CYP19A1
CYP19A1
SNP
CYP2C8
CYP2C8
SNP
CYP2D6
CYP2D6
SNP
SNV/INDELS
DAXX
DAXX
SNV/INDELS
DCUN1D1
DCUN1D1
SNV/INDELS
DDR1
DDR1
SNV/INDELS
DDR2
DDR2
SNV/INDELS
DICER1
DICER1
SNV/INDELS
DIS3
DIS3
SNV/INDELS
DKK3
DKK3
SNV/INDELS
DNMT1
DNMT1
SNV/INDELS
DNMT3A
DNMT3A
SNV/INDELS
DOT1L
DOT1L
SNV/INDELS
DPYD
DPYD
SNP
SNV/INDELS
DYNC2H1
DYNC2H1
SNP
EED
EED
SNV/INDELS
EIF1AX
EIF1AX
SNV/INDELS
EMSY
EMSY
SNV/INDELS
ENG
ENG
SNP
EP300
EP300
SNV/INDELS
EPAS1
EPAS1
SNV/INDELS
EPCAM
EPCAM
SNV/INDELS
EPHA3
EPHA3
SNV/INDELS
EPHA5
EPHA5
SNV/INDELS
EPHA6
EPHA6
SNV/INDELS
EPHA7
EPHA7
SNV/INDELS
EPHB1
EPHB1
SNV/INDELS
ERBB3
ERBB3
SNV/INDELS
ERCC1
ERCC1
SNP
SNV/INDELS
ERCC2
ERCC2
SNV/INDELS
ERCC3
ERCC3
SNV/INDELS
ERRFI1
ERRFI1
SNV/INDELS
ETS2
ETS2
SNV/INDELS
EZH2
EZH2
SNV/INDELS
F2R
F2R
SNP
FANCA
FANCA
HD
SNV/INDELS
FANCC
FANCC
SNV/INDELS
FANCD2
FANCD2
SNV/INDELS
FANCE
FANCE
SNV/INDELS
FANCF
FANCF
SNV/INDELS
FANCG
FANCG
SNV/INDELS
FANCI
FANCI
SNV/INDELS
FANCL
FANCL
HD
SNV/INDELS
FANCM
FANCM
SNV/INDELS
FAS
FAS
SNV/INDELS
FAT1
FAT1
SNV/INDELS
FBXW7
FBXW7
SNV/INDELS
FCGR2B
FCGR2B
SNV/INDELS
FGF10
FGF10
SNV/INDELS
FGF14
FGF14
SNV/INDELS
FGF19
FGF19
CNV
SNV/INDELS
FGF23
FGF23
SNV/INDELS
FGF3
FGF3
CNV
SNV/INDELS
FGF4
FGF4
SNV/INDELS
FGF6
FGF6
SNV/INDELS
FGF7
FGF7
SNV/INDELS
FGR
FGR
SNV/INDELS
FH
FH
SNV/INDELS
FLCN
FLCN
SNV/INDELS
FLT1
FLT1
SNV/INDELS
FLT4
FLT4
SNV/INDELS
FOXA1
FOXA1
SNV/INDELS
FOXL2
FOXL2
SNV/INDELS
FOXP1
FOXP1
SNV/INDELS
FRS2
FRS2
SNV/INDELS
FUBP1
FUBP1
SNV/INDELS
FUS
FUS
FUSIONS
SNV/INDELS
FYN
FYN
SNV/INDELS
GABRA6
GABRA6
SNV/INDELS
GATA1
GATA1
SNV/INDELS
GATA2
GATA2
SNV/INDELS
GATA3
GATA3
SNV/INDELS
GATA4
GATA4
SNV/INDELS
GATA6
GATA6
SNV/INDELS
GEN1
GEN1
SNV/INDELS
GLI1
GLI1
SNV/INDELS
GNA11
GNA11
SNV/INDELS
GNA13
GNA13
SNV/INDELS
GNAQ
GNAQ
SNV/INDELS
GNAS
GNAS
SNV/INDELS
GREM1
GREM1
SNV/INDELS
GRIN2A
GRIN2A
SNV/INDELS
GRM3
GRM3
SNV/INDELS
GSK3B
GSK3B
SNV/INDELS
GSTP1
GSTP1
SNP
SNV/INDELS
H1-2
H1-2
SNV/INDELS
H2BC5
H2BC5
SNV/INDELS
H3-3A
H3-3A
SNV/INDELS
H3-5
H3-5
SNV/INDELS
H3C2
H3C2
SNV/INDELS
HAMP
HAMP
SNP
HAVCR2
HAVCR2
SNV/INDELS
HCK
HCK
SNV/INDELS
HDAC2
HDAC2
HD
SNV/INDELS
HGF
HGF
CNV
SNV/INDELS
HIF1A
HIF1A
SNP
SNV/INDELS
HLA-B
HLA-B
SNV/INDELS
HLA-C
HLA-C
SNV/INDELS
HNF1A
HNF1A
SNV/INDELS
HOXB13
HOXB13
SNV/INDELS
HRAS
HRAS
SNV/INDELS
HSD3B1
HSD3B1
SNV/INDELS
HSP90AA1
HSP90AA1
SNV/INDELS
HSPB1
HSPB1
SNP
ICOS
ICOS
SNV/INDELS
ICOSLG
ICOSLG
SNV/INDELS
IDH1
IDH1
SNV/INDELS
IDH2
IDH2
SNV/INDELS
IFNGR1
IFNGR1
SNV/INDELS
IFNGR2
IFNGR2
SNV/INDELS
IGF1
IGF1
SNV/INDELS
IGF1R
IGF1R
CNV
SNV/INDELS
IGF2
IGF2
SNV/INDELS
IKBKE
IKBKE
SNV/INDELS
IKZF1
IKZF1
SNV/INDELS
IL13
IL13
SNP
IL1A
IL1A
SNP
IL4
IL4
SNP
IL6
IL6
SNP
IL7R
IL7R
SNV/INDELS
INHBA
INHBA
SNV/INDELS
INPP4A
INPP4A
SNV/INDELS
INPP4B
INPP4B
SNV/INDELS
INSR
INSR
SNV/INDELS
IP6K1
IP6K1
SNV/INDELS
IRF1
IRF1
SNV/INDELS
IRF2
IRF2
SNV/INDELS
IRF4
IRF4
SNV/INDELS
IRS2
IRS2
SNV/INDELS
ITGB2
ITGB2
SNP
ITGB6
ITGB6
SNP
JAK1
JAK1
SNV/INDELS
JAK3
JAK3
SNV/INDELS
JUN
JUN
SNV/INDELS
KDM5A
KDM5A
SNV/INDELS
KDM5C
KDM5C
SNV/INDELS
KDM6A
KDM6A
SNV/INDELS
KDR
KDR
SNV/INDELS
KEAP1
KEAP1
SNV/INDELS
KEL
KEL
SNV/INDELS
KLF4
KLF4
SNV/INDELS
KLHL6
KLHL6
SNV/INDELS
KMT2A
KMT2A
SNV/INDELS
KMT2B
KMT2B
SNV/INDELS
KMT2C
KMT2C
SNV/INDELS
KMT2D
KMT2D
SNV/INDELS
KRAS
KRAS
SNV/INDELS
LAG3
LAG3
SNV/INDELS
LATS1
LATS1
SNV/INDELS
LATS2
LATS2
SNV/INDELS
LCK
LCK
SNV/INDELS
LGALS3
LGALS3
SNP
LIG4
LIG4
SNP
LIN28B
LIN28B
SNP
LMO1
LMO1
SNV/INDELS
LRP1B
LRP1B
SNV/INDELS
LYN
LYN
SNV/INDELS
LZTR1
LZTR1
SNV/INDELS
MAGI2
MAGI2
SNV/INDELS
MAP2K1
MAP2K1
SNV/INDELS
MAP2K2
MAP2K2
SNV/INDELS
MAP2K4
MAP2K4
SNV/INDELS
MAP3K1
MAP3K1
SNV/INDELS
MAP3K13
MAP3K13
SNV/INDELS
MAP3K14
MAP3K14
SNV/INDELS
MAPK1
MAPK1
CNV
SNV/INDELS
MAPK3
MAPK3
SNV/INDELS
MAPK4
MAPK4
SNV/INDELS
MAX
MAX
SNV/INDELS
MCL1
MCL1
SNV/INDELS
MDC1
MDC1
SNV/INDELS
MDM2
MDM2
CNV
SNV/INDELS
MDM4
MDM4
CNV
SNV/INDELS
MED12
MED12
SNV/INDELS
MEF2B
MEF2B
SNV/INDELS
MEN1
MEN1
SNV/INDELS
MGA
MGA
SNV/INDELS
MGME1
MGME1
SNV/INDELS
MGMT
MGMT
SNP
MIF
MIF
SNP
MITF
MITF
SNV/INDELS
MKI67
MKI67
SNV/INDELS
MLH1
MLH1
SNV/INDELS
MLH3
MLH3
SNV/INDELS
MMP1
MMP1
SNP
MMP7
MMP7
SNP
MPL
MPL
SNV/INDELS
MPO
MPO
SNP
MRE11
MRE11
SNV/INDELS
MSH2
MSH2
SNP
SNV/INDELS
MSH3
MSH3
SNP
SNV/INDELS
MSH6
MSH6
SNV/INDELS
MST1R
MST1R
SNV/INDELS
MT2A
MT2A
SNP
MTHFR
MTHFR
SNP
MTOR
MTOR
SNV/INDELS
MTRR
MTRR
SNP
MUC16
MUC16
SNV/INDELS
MUC5B
MUC5B
SNP
MUTYH
MUTYH
SNV/INDELS
MYC
MYC
CNV
SNV/INDELS
MYCL
MYCL
SNV/INDELS
MYCN
MYCN
SNV/INDELS
MYD88
MYD88
SNV/INDELS
MYOD1
MYOD1
SNV/INDELS
NAA11
NAA11
SNV/INDELS
NBN
NBN
SNV/INDELS
NCOA3
NCOA3
SNV/INDELS
NCOR1
NCOR1
SNV/INDELS
NEIL1
NEIL1
SNP
NF1
NF1
SNV/INDELS
NF2
NF2
SNV/INDELS
NFE2L2
NFE2L2
SNP
SNV/INDELS
NFKB1
NFKB1
SNP
NFKBIA
NFKBIA
SNP
SNV/INDELS
NKX2-1
NKX2-1
SNV/INDELS
NOS2
NOS2
SNP
NOS3
NOS3
SNP
NOTCH1
NOTCH1
SNV/INDELS
NOTCH3
NOTCH3
SNV/INDELS
NOTCH4
NOTCH4
SNV/INDELS
NQO1
NQO1
SNP
NR1I2
NR1I2
SNP
NRAS
NRAS
SNV/INDELS
NUP93
NUP93
SNV/INDELS
NUTM1
NUTM1
FUSIONS
SNV/INDELS
OXSR1
OXSR1
SNV/INDELS
PAK1
PAK1
SNV/INDELS
PAK3
PAK3
SNV/INDELS
PAK5
PAK5
SNV/INDELS
PALB2
PALB2
HD
SNV/INDELS
PAPPA2
PAPPA2
SNV/INDELS
PARP1
PARP1
SNV/INDELS
PAX3
PAX3
FUSIONS
SNV/INDELS
PAX5
PAX5
SNV/INDELS
PAX7
PAX7
FUSIONS
SNV/INDELS
PBRM1
PBRM1
SNV/INDELS
PDCD1
PDCD1
SNV/INDELS
PDCD1LG2
PDCD1LG2
SNV/INDELS
PDK1
PDK1
SNV/INDELS
PDPK1
PDPK1
SNV/INDELS
PEG3
PEG3
SNV/INDELS
PGR
PGR
CNV
SNV/INDELS
PHF6
PHF6
SNV/INDELS
PIK3C2B
PIK3C2B
SNV/INDELS
PIK3C2G
PIK3C2G
SNV/INDELS
PIK3C3
PIK3C3
SNV/INDELS
PIK3CA
PIK3CA
CNV
SNP
SNV/INDELS
PIK3CB
PIK3CB
SNV/INDELS
PIK3CD
PIK3CD
SNV/INDELS
PIK3CG
PIK3CG
SNV/INDELS
PIK3R1
PIK3R1
SNV/INDELS
PIK3R2
PIK3R2
SNV/INDELS
PIM1
PIM1
SNV/INDELS
PLCG2
PLCG2
SNV/INDELS
PLK2
PLK2
SNV/INDELS
PMS1
PMS1
SNV/INDELS
PMS2
PMS2
SNV/INDELS
PNRC1
PNRC1
SNV/INDELS
POLD1
POLD1
SNV/INDELS
POLE
POLE
SNV/INDELS
POLE4
POLE4
SNV/INDELS
PPP2R1A
PPP2R1A
SNV/INDELS
PPP2R2A
PPP2R2A
HD
SNV/INDELS
PRDM1
PRDM1
SNV/INDELS
PRDX6
PRDX6
SNP
PREX2
PREX2
SNV/INDELS
PRKAA1
PRKAA1
SNV/INDELS
PRKACA
PRKACA
SNV/INDELS
PRKCI
PRKCI
SNV/INDELS
PRKDC
PRKDC
SNV/INDELS
PRKN
PRKN
SNV/INDELS
PRSS8
PRSS8
SNV/INDELS
PSMD4
PSMD4
SNV/INDELS
PTCH1
PTCH1
SNV/INDELS
PTEN
PTEN
HD
SNV/INDELS
PTGS2
PTGS2
SNP
PTPN11
PTPN11
SNV/INDELS
PTPRD
PTPRD
SNV/INDELS
PTTG1
PTTG1
SNP
PXDNL
PXDNL
SNV/INDELS
RAC1
RAC1
SNV/INDELS
RAD21
RAD21
SNV/INDELS
RAD50
RAD50
SNV/INDELS
RAD51
RAD51
SNP
SNV/INDELS
RAD51B
RAD51B
HD
SNV/INDELS
RAD51C
RAD51C
HD
SNV/INDELS
RAD51D
RAD51D
HD
SNV/INDELS
RAD52
RAD52
SNV/INDELS
RAD54L
RAD54L
HD
SNV/INDELS
RASA1
RASA1
SNV/INDELS
RASAL1
RASAL1
SNV/INDELS
RB1
RB1
SNV/INDELS
RBM10
RBM10
SNV/INDELS
RECQL
RECQL
SNP
RECQL4
RECQL4
SNV/INDELS
REL
REL
SNV/INDELS
REV3L
REV3L
SNP
RHEB
RHEB
SNV/INDELS
RHOA
RHOA
SNV/INDELS
RICTOR
RICTOR
CNV
SNV/INDELS
RIPK4
RIPK4
SNV/INDELS
RIT1
RIT1
SNV/INDELS
RNASEL
RNASEL
SNP
RNF43
RNF43
SNV/INDELS
ROBO2
ROBO2
SNV/INDELS
RPPH1
RPPH1
SNV/INDELS
RPS6KB1
RPS6KB1
SNV/INDELS
RPS6KB2
RPS6KB2
SNP
SNV/INDELS
RPTOR
RPTOR
SNV/INDELS
RSF1
RSF1
SNV/INDELS
RUNX1
RUNX1
SNV/INDELS
RUNX1T1
RUNX1T1
SNV/INDELS
SCN8A
SCN8A
SNV/INDELS
SDHA
SDHA
SNV/INDELS
SDHAF2
SDHAF2
SNV/INDELS
SDHB
SDHB
SNV/INDELS
SDHC
SDHC
SNV/INDELS
SDHD
SDHD
SNV/INDELS
SEMA3C
SEMA3C
SNP
SERPINB3
SERPINB3
SNV/INDELS
SERPINB4
SERPINB4
SNV/INDELS
SERPINE1
SERPINE1
SNP
SETBP1
SETBP1
SNV/INDELS
SETD2
SETD2
SNV/INDELS
SF3B1
SF3B1
SNV/INDELS
SIK1
SIK1
SNV/INDELS
SKP2
SKP2
SNV/INDELS
SLC28A3
SLC28A3
SNP
SLC47A1
SLC47A1
SNP
SLCO1B1
SLCO1B1
SNP
SLIT2
SLIT2
SNV/INDELS
SLX4
SLX4
SNV/INDELS
SMAD2
SMAD2
SNV/INDELS
SMAD3
SMAD3
SNV/INDELS
SMAD4
SMAD4
SNV/INDELS
SMARCA4
SMARCA4
SNV/INDELS
SMARCB1
SMARCB1
SNV/INDELS
SMARCD1
SMARCD1
SNV/INDELS
SMO
SMO
CNV
SNV/INDELS
SNCAIP
SNCAIP
SNV/INDELS
SOCS1
SOCS1
SNV/INDELS
SOD2
SOD2
SNP
SOX10
SOX10
SNV/INDELS
SOX17
SOX17
SNV/INDELS
SOX2
SOX2
SNV/INDELS
SOX9
SOX9
SNV/INDELS
SPEN
SPEN
SNV/INDELS
SPOP
SPOP
SNV/INDELS
SPTA1
SPTA1
SNV/INDELS
SRC
SRC
SNV/INDELS
SRSF2
SRSF2
SNV/INDELS
STAG2
STAG2
SNV/INDELS
STAT4
STAT4
SNV/INDELS
STK11
STK11
SNV/INDELS
SUFU
SUFU
SNV/INDELS
SUZ12
SUZ12
SNV/INDELS
SYK
SYK
SNV/INDELS
TAF1
TAF1
SNV/INDELS
TAOK1
TAOK1
SNV/INDELS
TBX3
TBX3
SNV/INDELS
TCF7L1
TCF7L1
SNV/INDELS
TCF7L2
TCF7L2
SNV/INDELS
TENT5C
TENT5C
SNV/INDELS
TERT
TERT
SNV/INDELS
TET1
TET1
SNV/INDELS
TET2
TET2
SNV/INDELS
TGFB1
TGFB1
SNP
TGFBR2
TGFBR2
SNP
SNV/INDELS
TIGIT
TIGIT
SNV/INDELS
TMEM127
TMEM127
SNV/INDELS
TNF
TNF
SNP
TNFAIP3
TNFAIP3
SNV/INDELS
TNFRSF14
TNFRSF14
SNV/INDELS
TNFRSF18
TNFRSF18
SNV/INDELS
TNFRSF9
TNFRSF9
SNV/INDELS
TOP1
TOP1
SNV/INDELS
TOP2A
TOP2A
CNV
SNV/INDELS
TPMT
TPMT
SNV/INDELS
TRAF3
TRAF3
SNP
TRAF7
TRAF7
SNV/INDELS
TRRAP
TRRAP
SNV/INDELS
TSC1
TSC1
SNV/INDELS
TSC2
TSC2
SNV/INDELS
TSHR
TSHR
SNV/INDELS
TXNRD2
TXNRD2
SNP
TYMS
TYMS
SNP
U2AF1
U2AF1
SNV/INDELS
UGT1A1
UGT1A1
SNP
UMPS
UMPS
SNP
VEGFA
VEGFA
SNP
SNV/INDELS
VHL
VHL
SNV/INDELS
WRN
WRN
SNV/INDELS
WT1
WT1
SNV/INDELS
XPC
XPC
SNP
SNV/INDELS
XPO1
XPO1
SNV/INDELS
XRCC1
XRCC1
SNP
SNV/INDELS
XRCC2
XRCC2
SNV/INDELS
XRCC3
XRCC3
SNP
XRCC4
XRCC4
SNP
XRCC5
XRCC5
SNP
YES1
YES1
SNV/INDELS
ZBTB2
ZBTB2
SNV/INDELS
ZFHX4
ZFHX4
SNV/INDELS
ZNF217
ZNF217
SNV/INDELS
ZNRF3
ZNRF3
SNV/INDELS
ZRSR2
ZRSR2
SNV/INDELS
Specifications
Target regions
DNA: 571 genes; RNA: 2660 genes
Alterations detected
DNA: SNVs/Indels, Fusions, CNV, TMB, MSI, HRD;
RNA: Fusions, GeneExp, GEP, TME, EBV
RNA: Fusions, GeneExp, GEP, TME, EBV
Data output per sample
DNA: 10Gb; RNA: 2Gb
Sequencer
Illumina NovaSeq 6000; NextSeq 500/550
Publications
1. Kunimasa, K., Matsumoto, S., Honma, K. et al. Utility of needle biopsy in centrally located lung cancer for genome analysis: a retrospective cohort study. BMC Pulm Med 23, 484 (2023).
2. Atsushi OHTSU, Koichi GOTO, Takayuki YOSHINO. Improvement of patient care using cancer genomic profiling: SCRUM-/CIRCULATE-Japan experience. Proceedings of the Japan Academy, Series B, 2023, Volume 99, Issue 8, Pages 241-253.
3. Li S, Hou L, Huang Y, et alPrimary salivary duct carcinoma of the lung: clinicopathological features, diagnosis and practical challengesJournal of Clinical Pathology Published Online First: 25 January 2023.
Inquiry