EGFR 29 Mutations Detection Kit
PCR
Real-time PCR Assays
29
Mutations
100%
100%
Specificity
100%
100%
Accuracy
1%
1%
Sensitivity
Features
Selectable
- Pre-loaded and bulk formats are available.
1
- Pre-loaded and bulk formats are available.
Universal
- Compatible with tissue, peripheral blood samples.
2
- Compatible with tissue, peripheral blood samples.
Precise
- Top sensitivity of 1% mutant allele.
3
- Top sensitivity of 1% mutant allele.
Easy
- One-step procedure, results in 90 mins.
4
- One-step procedure, results in 90 mins.
Reliable
- Internal and external controls included.
5
- Internal and external controls included.
Product Description

EGFR 29 Mutations Detection Kit

The epidermal growth factor receptor (EGFR) plays a central role in transmitting signals that promote cell growth and proliferation. Due to its association with malignancies, EGFR has become the target of an expanding class of anticancer therapies, such as gefitinib, erlotinib and afatinib, which are tyrosine kinase inhibitors (TKIs). The TKIs target the EGFR tyrosine kinase domain. These drugs work best on non-small cell lung cancer (NSCLC) patients whose cancer is driven by abnormal EGFR signaling. Lung cancer patients who experienced rapid, durable, complete or partial responses to TKI therapy have been found to harbor somatic mutations in EGFR gene. NSCLC patients with sensitizing EGFR mutations treated with TKI therapy have shown longer progression-free survival and higher response rate, compared with conventional chemotherapy. Resistance to TKI therapy, either in the primary tumor or acquired after TKI treatment, is associated with EGFR T790M mutation. Therefore, assessment of EGFR mutation status facilitates personalized treatment to lung cancer patients.

Intended Use

The AmoyDx® EGFR 29 Mutations Detection Kit is a real-time PCR assay for qualitative detection of 29 somatic mutations in exons 18, 19, 20 and 21 of EGFR gene in human genomic DNA extracted from formalin-fixed paraffin-embedded (FFPE) tumor tissue, or circulating DNA extracted from plasma/serum. The kit is intended to assess EGFR mutation status in NSCLC patients and aid in identifying patients who may respond to the treatment with an EGFR-TKI.

The kit is for in vitro diagnostic use, and intended to be used by trained professionals in a laboratory environment.

Testing Procedure
Compatible Sample Types:FFPE tissue or plasma/serum samples
Compatible Real-time PCR Instrument
cobas® z480
ABI 7300
ABI 7500
ABI 7900 HT
ABI StepOnePlus
Bio-Rad CFX96
LightCycler 480
Rotor-Gene 6000
Rotor-Gene Q
SLAN-96S
Stratagene Mx3000P™
Other Info.

To order, please contact sales@amoydx.com.
 

 Product Name Tests/Kit  Storage
EGFR 29 Mutations Detection Kit (Pre-loaded) 10T -20℃
 EGFR 29 Mutations Detection Kit (Bulk)  24T -20℃




 

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