Super-ARMS® EGFR Mutation Detection Kit
The best solution for Plasma EGFR Mutation Testing
PCR
Ensayos de PCR en tiempo real
100%
100%
Specificity
42
Mutations
0.2~0.8%
0.2~0.8%
Sensitivity
89.9%*
89.9%*
Overall Agreement
Features
Specific
- Specific designed for plasma testing.
1
- Specific designed for plasma testing.
Universal
- Compatible with tissue and plasma samples.
2
- Compatible with tissue and plasma samples.
Precise
- Top sensitivity of 0.2% mutant allele.
3
- Top sensitivity of 0.2% mutant allele.
Extensive
- Covers 42 most frequent EGFR mutations.
4
- Covers 42 most frequent EGFR mutations.
Rapid
- One-step procedure, results in 120 minutes.
5
- One-step procedure, results in 120 minutes.
Product Description

Super-ARMS® EGFR Mutation Detection Kit

Currently there are several EGFR-TKIs approved for NSCLC (Non-small Cell Lung Cancer) targeted therapy including first-generation TKIs (gefitinib and erlotinib), second-generation TKI (afatinib) and third-generation TKI (osimertinib). To select right patients for these therapies, it is essential to detect EGFR mutation status before the treatment decision.

NSCLC tissue testing has been applied to EGFR mutation detection for years. However, up to 25% of patients with advanced or metastatic NSCLC do not have an available or sufficient tumor tissue sample for this method of testing. More and more dynamic monitoring demand for EGFR mutation status appears. When tissue sample is not a reliable or realistic option, the ctDNA (circulating tumor DNA) obtained from blood sample can be used for the assessment of EGFR mutation status.

Super-ARMS® EGFR kit is a highly sensitive, real-time PCR-based test which is designed to identify ctDNA EGFR mutation in plasma samples for patients with advanced or metastatic NSCLC. The kit adopts innovative Super-ARMS® technology which is upgraded from ADx-ARMS technology. Its optimized reaction system can rapidly and accurately detect low percentage of mutant ctDNA in a background of wild-type DNA.
 

Technological Principles:

The Super-ARMS® EGFR mutation kit enables detection of the following 42 EGFR mutations:

• Exon 18: G719C, G719A, G719S

• Exon 19: 29 deletions

• Exon 20: T790M, S768I, 6 insertions

• Exon 21: L858R, L861Q

Testing Procedure
Compatible Sample Types: Tissue or Plasma samples
Compatible Real-time PCR Instrument
ABI 7500
LightCycler 480
SLAN-96S
Stratagene Mx3000P™
Other Info.

To order, please contact sales@amoydx.com.

Super-ARMS® EGFR Mutation Detection Kit is available in the following size:

 Product Name

Size (test/kit)

 Storage

 Cat. No.

Super-ARMS® EGFR Mutation Detection Kit (Bulk)

12T

-20℃

8.01.20213X012E

Super-ARMS® EGFR T790M Mutation Detection Kit (Bulk)

 24T

-20℃

8.01.20212X024D

* Li, Yuping, et al. "Clinical validation of a highly sensitive assay to detect EGFR mutations in plasma cell-free DNA from patients with advanced lung adenocarcinoma." PloS one 12.8 (2017): e0183331.

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